All biological systems have developed their own signaling machinery within a cell or between cells. To understand biological systems have developed their own signaling machinery within a cell or between cells. To understand broad range of molecular communications from basics to applications, we seek to elucidate molecular, cellular, and organismic signaling mechanism in diverse model systems such as neuronal system, stem cell, cancer and disease models. In this track, students can learn establishment of model system for brain function and emotional control mechanisms, roles of biomolecule in cancer, aging, and metabolism, disease progression in hypoxic and inflammatory microenvironment, genomewide signaling networks, and development of optical instrumentation for biomedical imaging. Also students can have a chance to collaborate with foreign scholars involved in this track to broaden our research interests in depth, such as insulin signaling in diabetes, protein-protein-lipid interactions, gene regulatory mechanism for cell fate determination, and molecular network coordinating metabolism and cell growth. Eventually we hope our research could contribute to healthy life without disease, medical care for health improvement, and life span extension.