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IBB POSTECH

Faculty

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Lab : Immune regulation and tolerance
Office : + 82-54-279-2356 / Lab: + 82-54-279-0646
Homepage : irt.postech.ac.kr
E-Mail :

Profile

Division of Integrative Biosciences and Biotechnology
Immune regulation and tolerance 

 

1991-1996 : Senior Research Scientist, Research Center of Chong Kun Dang Pharmaceutical Company, Seoul, Korea. 

 

2001-2003 Postdoctoral Fellow, Department of Pathology Harvard Medical School 

 

2004-2008 Assistant Professor, School of Life Sciences, Gwangju Institute of Science and Technology (GIST) 

 

2008-2012 Associate Professor, School of Life Sciences, Gwangju Institute of Science and Technology (GIST) 

 

2012-2013 Professor, School of Life Sciences, Gwangju Institute of Science and Technology (GIST) 

 

2014~present : Professor, Division of Integrative Biosciences and Biotechnology, POSTECH


Research Interests

• Role of transcription factors (Ets1 and NFAT1) in immune regulation and tolerance
• Molecular mechanism of IL-10 gene regulation in lymphocytes and dendritic cells
• Elucidation of the signaling pathways for IL-10 expression induced by commensal bacteria and probiotics.
• Elucidation of the mechanism of probiotics-induced immune modulation
• Characterization of regulatory DCs and regulatory T cells (iTreg) cells induced by probiotics
• Development of antigen-specific immunotherapy for autoimmune disorders (Myasthenia gravis and rheumatoid arthritis)

Selected Publications

1. Kwon HK, Kim GC, Kim Y, Hwang W, Jash A, Sahoo A Nam JH, and Im SH. Amelioration of experimental autoimmune encephalomyelitis by probiotics mixture is mediated by a shift in T helper cell immune response. Clinical Immunology. 2013;146(3):217-227

2. Chae CS, Kwon HK, Hwang JS, Im SH. Prophylactic effect of probiotics on the development of experimental autoimmune myasthenia gravis. PLoS One. 2012;7(12):e52119

3. Lee IH, Kwon HK, An S, Kim D, Kim S, Yu MK, Lee JH, Lee TS, Im SH, Jon S. Imageable Antigen-Presenting Gold Nanoparticle Vaccines for Effective Cancer Immunotherapy In Vivo. Angew Chem Int Ed Engl. 2012;51(35):8800-5

4. Jash A, Sahoo A, Kim GC, Chae CS, Hwang JS, Kim JE, ImSH. NFAT induced permissive chromatin modification facilitates NF-κB mediated interleukin-9 (IL-9) transactivation. J Biol Chem. 2012;287(19):15445-57

5. Jash A, Yun KS, Sahoo A, So JS, Im SH. Looping mediated interaction between the promoter and 3′ UTR regulates type II collagen expression in chondrocytes. PLoS One. 2012;7(7):e40828.

6. Lee CG, Kwon HK, Sahoo A, Won H, So JS, Hwang JS, Chae CS, Kim GC, So HS, Hwang ES, Grenningloh R, Ho IC and ImSH. Interaction of Ets-1 with HDAC1 represses IL-10 expression in T helper 1 cells. J Immunol. 2012;188(5):2244-253

7. Son JS, Chae CS, Hwang JS, Park ZY, Im SH. Enhanced chromatin accessibility and recruitment of JUNB mediate the sustained IL-4 expression in NFAT1 deficient T helper 2 cells. PLoS One. 2011. 6(7): e22042

8. Lee IH, An S, Yu MK, Kwon HK, Im SH, Jon S. Targeted chemoimmunotherapy using drug-loaded aptamer-dendrimer bioconjugates. J Control Release. 2011; 155(3):435-41

9. Sahoo A, Lee CG, Jash A, Son JS, Kim G, Kwon HK, So JS, Im SH. Stat6 and c-Jun Mediate Th2 Cell-Specific IL-24 Gene Expression. J Immunol. 2011;186(7):4098-109

10. So JS, Song MK, Kwon HK a, Lee CG, Chae CS, Sahoo A, Jash A, Lee SH, Park ZY and Im SH. Lactobacillus casei enhances type II collagen/glucosamine-mediated suppression of inflammatory responses in experimental osteoarthritis. Life Sci. 2011;88(7-8):358-66

11. Kwon HK, Lee CG, Jae-Seon Soa, Chae CS, Hwang JS, Sahoo A, Nam JH, Rhee JH, Hwang KC, and Im SH Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders; Proc Natl Acad Sci U S A. 2010;107(5):2159-64. Commented by J Allergy Clin Immunol . May 2010. Page 953

12. Sahoo A and Im SH Interleukin and Interleukin Receptor Diversity: Role of Alternative Splicing. Int Rev Immunol. 2010;29(1):77-109

13. Lee CG, Won H, Maeng KE, Kwon HK, So JS, Sahoo A, Lee SH, Park ZY, ImSH. IRF4 regulates IL-10 gene expression in CD4+ T cells through differential nuclear translocation. Cell Immunol 2011;268: 97-104

14. Yun KS, So JS, Jash A and Im SH Lef1 regulates transcription through gene looping. J Immunol 2009 Oct 15;183(8):5129-37

15. CG Lee, KH Kang, JS So, HK Kwon, JS Son, MK Song, A Sahoo, HJ Yi, KC Hwang, T Matsuyama, K Yui, SH Im. A distal cis-regulatory element, CNS-9, controls NFAT1 and IRF4-mediated IL-10 gene activation in T helper cells. Mol Immunol. 2009 Feb;46(4):613-21

16. Kwon HK, Jeon WK, Hwang JS, Lee CG, So JS, Park JA, Ko BS, Im SH. Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8(+) T cells. Cancer Lett. 2009; 278(2): 174-182

17. Lee CG, Kang KH, So JS, Kwon HK, JS Son JS, Song MK, Sahoo A, HJ HJ, KC Hwang, Matsuyama T, Yui K, Im SH. A distal cis-regulatory element, CNS-9, controls NFAT1 and IRF4-mediated IL-10 gene activation in T helper cells. Mol Immunol. 2009;46(4):613-21

18. Sahoo A, Jung YM, Kwon HK, Yi HJi, Lee S, Chang S, Park ZY, Hwang KC, Im SH. A novel splicing variant of mouse IL-24 antagonizes IL-24-induced apoptosis. J Biol Chem. 2008. 43: 28860-28872.

19. Yi HJ, CS Chae, JS So, ST Tzartos, MC Souroujon, S Fuchs, SH Im. Suppression of Experimental Myasthenia Gravis by a B-cell Epitope-Free Recombinant Acetylcholine Receptor. Mol Immunol. 2008.09.15. 46(1):192-201

20. So JS, CG Lee, HK Kwon ,HJ Yi, CS Chae, JA Park, KC Hwang, SH Im. Lactobacillus casei potentiate induction of oral tolerance in experimental arthritis. Mol Immunol. 2008.09.18. 46(1):172-180

21. So JS, HK Kwon, CG Lee, HJ Yi, JA Park, SY Lim, KC Hwang, YH Jeon, SH Im. Lactobacillus casei suppresses experimental arthritis by down-regulating T helper 1 effector functions. Mol Immunol. 2008.02.19. 45(9):2690-2699