The course is designed to present the state-of-the-art technology for high resolution imaging of the micro structure of living organisms. The course also offers in-vivo dynamic research of the micro structure of cells and living organisms.
This course covers both basic and advanced level topics related to biological membrane systems and their components, lipids and membrane proteins. Topics include lipid metabolism and transport, lipid signaling, membrane trafficking, membrane domains, membrane proteins, membrane-cytoskeleton interactions, membrane-protein interactions, cell-cell communication, and methodologies to study biological membranes.
This course explores the structures and regulation of receptors and ionic channels, and the molecular regulatory mechanisms of factors in signal pathways that emanate from them. In addition, the principles of enzyme chemical structures, functions, and application and related metabolic pathways and their significance as well as contemporary research techniques are addressed. In particular, emphasis is placed on enzyme kinetics, reaction mechanisms, and active sites, labeling and determination techniques, structural relationships among active inhibitors and active sites, and the modification of enzymes using genetic engineering and gene expression.
This course explores the basic principles of the organization and reactions of the nervous systems of various life forms. In particular, emphasis is placed on neurocytology, the structure of the nervous system, the development of nerves, and the biochemical mechanisms of action potential and transmission and of sensory transduction.
This course comprehensively explore the basic principles of regulating hormones, neuro-transmitters, growth factors, and cells’ reactions to changes in the external environment, components of receptors, switches, amplification systems, and molecular networks on a molecular level, various forms of signal transduction, as well as the growth, development, differentiation, and death of cells.
For a good understanding of overall research programs and integration in the division, in this class each faculty member will introduce graduate students, in particular freshman, his/her current research topics and their efforts for integrative studies with other faculty members.
This course covers advanced-level topics on proteins and proteomics. Topics include protein structure, stability, regulation, folding, interactions, dynamics, modification and degradation.
The goals of this course are to provide a broad overview of the principles and applications of optical technologies that are being widely used or newly emerging in various scientific fields. It also introduces students cutting-edge imaging and research tools to allow unpresendent biological research performed with cells in living subjects and to develop new ways to diagnose diseases. Accordingly, the course is open to under and graduate students with diverse backgrounds, such as material science, and mechanical engineering and physics, as well as biological sciences, who wish to learn one of fastest-developing techniques for biological research and medical intervention.
This course explores the structures of cells in relation to their functions, analysis of observations using optical and electron microscopes, and techniques for verifying the distribution of target proteins in cells using marked antibodies.
Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physio-chemical factors to improve or replace biological functions. This course teaches fundamentals that span several academic areas related to tissue engineering to students who have a mechanical engineering background, and introduces various approaches to research. Topics include basic cell biology, chemistry, bio-materials, anatomy, computer-aided design/computer-aided machining (CAD/ CAM), and manufacturing technology. Various mathematical and mechanical tools for simulating cell behavior are introduced. In addition, basic experimental laboratory instruction covers cell culture and scaffold fabrication.
Cell signalings are basic concepts for the understanding of energy homeostasis and control mechanism in living organisms. Especially, the relationships between the principles of signal transduction and the metabolic diseases such as diabetes and obesity will be focused to learn current trends and future subject of research in this area.
- The components and principles of signaling for major receptors, switches, 2nd messengers, protein kinases and scaffolds.
- The machineries and mechanisms for the control of energy homeostasis in living organisms.
- Current trends in the researches on the disorders in metabolism and diseases such as diabetes and obesity
Knowledge obtained from Plant science can be applied to improve the quality and quantity of food, energy, and to protect environment, and thus is becoming more and more important for our everyday life and world economy in 21st century. This course explores the current translational researches which attempt to connect the knowledge from basic plant science to application fields such as agriculture, industry, and environment. The course will consist of lectures from professors and student presentations. Occasionally invited speakers will give a lecture to the students in the class.
The course is designed to focus on basic and integrative Immunology for students who do not have immunology background (Beginner’s Immunology for engineering background).
In this course, students will learn how basic immunology research is translated and applied in the biomedical field for prevention and treatment of various diseases. The topics include monoclonal antibody therapy, cancer immunology, vaccination, immuno-suppressive drugs, transplantation, etc.
To understand diverse biological events, it is required to approach the scientific problems through integration of different disciplines. In this course, the recent published papers covering the interaction among nucleic acids, proteins, and lipids by state-of-art technologies will be introduced and discussed.
From an immunologic perspective, cancer cells can be viewed as altered self cells that have escaped normal growth-regulating mechanisms. Cancer cells are comprised of a heterogeneous cell population including cancer stem cells which are less differentiated and dividing slowly, accounting for drug resistance and thus the recurrence of many cancers. Tumor cells display tumor-specific antigens and the more common tumor associated antigens, which could be recognized by T cells and antibody. The tumor-specific immunity includes not only soluble cytotoxic factors such as TNF but also CTL-mediated lysis, NK-cell activity, and ADCC. However, cancer cells have developed several strategies to evade our immune system. Cancer immuno-therapy includes cell-based cancer vaccines and monoclonal antibodies directed against tumor antigens. Currently, key challenges in designing effective strategies for cancer immuno-therapies are the identification of tumor-specific antigens, the development of efficient way for presenting tumor antigens, and generation of strong humoral and cellular immunity.
This course is intended to provide engineering graduate students with basic knowledge of biology and covers an introductory topics on biochemistry, molecular biology, and cell biology.
This course is to provide introduction of bio-engineering related researches conducted by professors in mechanical engineering. This course will cover individual research topics such bio-dynamics, tissue engineering, bio-sensor technology, optical imaging technology with basic engineering principles of solid mechanics, dynamics, fluid mechanics.
This course focuses on transition metal based organometallic compounds. The concept of ligands and the rules of their coordinations to transition metals are introduced, which further provides concrete understandings about their optical, electrical, magnetic properties. The synthesis, chemical reactivity, characterization methods are also covered. In the last part, currently rising hot topics in materials chemistry are introduced.
In this subject, students will learn the organization of the eukaryotic cell, physiological roles of organelles, operating principles of eukaryotic cells, and the theory/hypothesis on the cellular evolution. Furthermore, students will learn the mechanism of protein translation, protein targeting to the ER, chloroplasts and mitochondria, protein trafficking between endo-membrane compartments, and proteins and lipid molecules involved in the protein trafficking. This class will consist of lectures, presentation and group discussion.
This course will introduce students to current findings and thinking inplant physiology, with a focus on development. The role of the basic plant hormones and light in controlling morphogenesis and physiology will be covered at the advanced level, with an emphasis on the most recent findings. Oral presentations from the primary literature will be a required part of student participation, with all activities in English. Students will present orally, and with appropriate visual aids, a paper that they will first outline and then critique in class. This will include analysis of what the primary questions are that were addressed in the paper and how far the authors went in obtaining the answers, what techniques were used and their appropriateness, and what follow-up work might be. This will be led primarily by the presenter(s), with contributions from the class, and moderated and guided by the instructor.
This course explores photosynthesis, metabolism, growth, reactions to the environment, plant-microbe interrelations, genesis, control and regulation, and hormonal reactions.
This course introduces principles in Oncology covering from the cellular and molecular levels to tissue levels including those in cancer patients. Particularly, students will learn how tumor microenvironment impacts cancer therapy and how chemotherapy and radiotherapy exert their anticancer actions at the tissue, cellular, and molecular levels. Students will also be exposed to some of the newest trends in Oncology including metastasis and cancer stem cells.
This course explores the principles of and techniques for conducting research on immunity and application for the resolution of major biological problems. In particular, emphasis is placed on the reactions of antigens and antibodies, immuno assay, structures and reactions of immuno-globulins, genes governing the immune system, processes through which antibodies are formed, principles of cell-mediated immunity, complements, tolerance, and transplantation, and techniques for producing and applying monoclonal antibodies.
Bio-dynamics deals with the living bodies in a view point of principles of mechanics. Especially treat the human body as biological and physiological object together with an applied engineering area. This course will cover related theories and analysis, and introduce up-to-date research trends. It also introduce in the areas of medical science, life-science, chemistry, mechanical engineering and chemical engineering, and the relationship between these areas.
This course introduces the structures and function of cellular meso(the size in tens and hundreds of nano-meters) architecture (cell organelles, vesicles, membrane signaling stations etc.)and explores the methodology for study of their biological functions.
Fluid flow in animals and plants including the circulatory motion in cardio-vascular system are studied. Rheological behavior of blood and blood cells are analyzed based on fluid dynamic principles, and then applied to the understanding of the causes and possible treatments for diseases with heart and circulatory system.
This course explores in depth DNA replication in lower cells, genetic recombination, DNA repair, structures and functions of genes, transposable elements, and gene expression regulation through the latest research and literature.
This course introduces life science related adjacent academic areas for cooperative research and helps students choose research topics.
The course analyses the emerging biotech industry, its prospects and research directions. In addition, the course introduces basic and novel technologies in biotech industry.
This course is to covers experimental insights and techniques to understand the phenomenon of life. Specifically, this course provides the basic biochemical and biophysical concepts, relation between structure, chemistry and property of bio-macromolecules (DNA, Protein, Carbohydrate, Bio-mimetic polymer).
This course explores the reactions of enzymes and substrates and enzyme reaction mechanisms on an atomic level. In particular, emphasis is placed on chemical methods, methods for studying enzyme mechanisms using enzyme proteins’ tertiary structures, electrons’pathways of movement during chemical reactions, and the roles and chemistry of co-enzymes.
This course explores in depth unique structures and functions of plant cells and examines the latest accomplishments, trends, and developments in research in this field. Recommended prerequisite: LIFE 506 Plant Physiology
This course explores techniques for conducting research on plant genome. In particular, emphasis is placed on rapidly developing areas of study including gene isolation, mutation induction, genome mapping, proteomics, and bio-informatics through an examination of the latest literature. Prerequisite: LIFE 510 Plant Molecular Biology
This course addresses ways of searching for and analyzing DNA and protein information, as well as providing insight into biological literature and the latest trends in and the future of bioinformatics.
This course explores special topics in integrative bioscience sand biotechnology as the professor’s discretion.
A novel feature of the graduate level course is an integrative analysis of complex biological systems. The course aims to develop fundamental principles for systems approaches:
1)formulation of key biological problems,
2)technologies for global data-sets and
3) computation for modeling and analysis via mining of such global data-sets and
4)integration of such data-sets with other relevant data. In the first half of the course, the course takes a rigorous mathematical approach with emphasis on the development of application of modern mathematical and computational methods. In the second half of the course, the course takes to develop basic principles to study spatio-temporal behaviors of biological systems via data integration at the system level.
This course is designed to explore the conversion and material transport of fine energy, related devices and behaviors through the mechanical, material, physical, chemical, and biological analysis of fine bio-materials and reactions. This course further discusses cases of Bio-MEMS devices and Micro/Nano Electro Mechanical Systems development for the high throughput analysis and treatment of fine bio-materials and related scientific and technological issues.
This course deals with design and synthesis of organic compounds such as natural products, various application of organic reactions, and synthetic application of stereochemistry.
As a partial fulfillment of a master degree, an independent research for a master thesis is conducted under the guidance of a designated thesis advisor.
In this course, students explores various techniques in plant molecular genetics through lectures, discussions, and experiments.
This course explores the molecular principles and diversity of cell-molecule interactions in multicellular life forms. Particular emphasis is placed on receptor ligands, which are the key molecular mechanisms that form the basis of intermolecular recognition for the regulation of cellular functions and signal transduction, the functional modules and motifs of signal proteins, and unique molecular interaction through lectures and presentations. In order to enhance students’mathematical and bio-informational understanding of communication in bio-systems consisting of such components, experts will give tutorial lectures.
This course explores DNA replication, chromosome stability, gene applicability, and regulation both before and after replication and before and after transcription.
This course explores the latest trends and hypothesis in immunology and students present their suggestion and discussion.
The immune system provides protection from infectious agents and cancer. The immune system can be divided into innate and adaptive immunity, which are mediated by various types of cells, including T and B lymphocytes, antigen presenting cells, natural killer cells, neutraphils and basophils. The goal of this class is to highlight the recent advances in key topics in immunology, with emphasis in T cell biology. The topics will include T cell homeostasis, activation, differentiation and memory generation. Signals that regulate T cell biology, including from antigen presenting cells and innate immunity will also be discussed.
Seminars for graduate students, which are related to all areas of interdisciplinary Bioscience and Bioengineering are delivered by invited speakers.
Graduate students working toward the Ph. D. degree are required to carry out Ph. D. dissertation research under the supervision of their thesis advisor.